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Myocardial infarction was the cause of death in two patients in the rofecoxib group and three in the placebo group, sudden death from cardiac causes occurred in three patients in the rofecoxib group and one in the placebo group, ischemic stroke was the cause of death in one patient in the rofecoxib group, and hemorrhagic stroke was the cause of death in one patient in the placebo group.
Do not use cosmetics, sunscreen, lotions, insect repellant, or other medicated skin products not prescribed by your doctor.
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For best results apply a cold pack, protecting the skin with a layer of towel, to the painful area for 20 minutes.
The products discussed herein may have different product labeling in other countries.
DISCUSSION: Knee osteoarthritis (OA) and backache are among the most common ailments of musculoskeletal diseases.
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QID dosing of said topical diclofenac solution; (ii) the effects of 40-drop QID dosing of said topical diclofenac solution in one or more clinical trials; (iii) results from a 12-week, double-blind, controlled trial of said topical diclofenac solution in subjects with osteoarthritis of the knee which compared the performance of said topical diclofenac solution against a vehicle solution containing 45.
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Initially, patients who were taking low-dose aspirin (no more than 100 mg daily) were excluded from the study.
In one aspect of this embodiment, the user or prescriber is further informed that the combination of topical diclofenac and oral diclofenac did not increase the incidence of digestive system events over oral diclofenac alone.
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Although serious skin reactions may occur without warning, patients should be alert for the signs and symptoms of skin rash and blisters, fever or other signs of hypersensitivity such as itching and should ask for medical advice when observing any indicative signs or symptoms.
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