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The bioavailability of betrixaban is about 35, with peak plasma concentrations occurring 3 to 4 hours after dosing. The halflife of betrixaban has been reported to range from 20 to 27 hours. To produce a rapid clinical response, the labeling recommends a 160mg loading dose, followed by 80 mg daily. 1 Food both high and lowfat diets reduces the mean bioavailability of betrixaban by 50 to 60. A minor portion of betrixaban is converted by amide hydrolysis to inactive metabolites. 1 Following intravenous administration, about 17 of betrixaban is recovered unchanged in the urine.
The problem with all these omics is that they are hideously complicated, with interactions of thousands of genes, proteins, and other entities that must be made sense of in order to understand what is going on. Indeed, arguably the reason we never bothered with these sorts of analyses before is that, until the last 1020 years quite simply they were impossible.
Blockbuster drugs are rarely discovered in a vacuum. They are the result of incremental steps in understanding the biology of disease, with an ever improving ability to target the offending pathophysiologic process. The first few therapies may offer marginally improved outcomes, but can lead to discoveries that substantially improve their efficacy.
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