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Similar findings, however, have been observed in normals or well-compensated patients with heart failure with agents possessing significant negative inotropic effects.
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After four weeks, the dose of losartan or placebo was increased to 100 mg or the placebo equivalent once daily if the trough blood pressure with the patient sitting was above the target level of a systolic blood pressure of less than 140 mm Hg and a diastolic blood pressure of less than 90 mm Hg.
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Conversely, in a substudy of the ACCORD trial, cognitive impairment at baseline or decline in cognitive function during the trial was significantly associated with subsequent episodes of severe hypoglycemia ().
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Amlodipine (5-10 mg per day) has been studied in a placebo-controlled trial of 1153 patients with New York Heart Association (NYHA) Class III or IV heart failure on stable doses of ACE inhibitor, digoxin, and diuretics.
In addition, concomitant use may further deteriorate renal function, especially in volume-depleted patients, patients with renal impairment, or in elderly patients.
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Although it has been shown that combination of ACE inhibitors and ARBs without β-blockers was useful in patients with symptomatic CHF, there has been a controversy for the effectiveness of the dual RAS blockade with ACE inhibitors and ARBs in patients with HFrEF treated with β-blockers.
IFG and IGT should not be viewed as clinical entities in their own right but rather risk factors for diabetes and cardiovascular disease (CVD).
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Angiotensin II is formed from angiotensin I in a reaction catalyzed by ACE, kininase II.
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